A brief history of pacemaking. Minireview Frontiers in Physiology

DiFrancesco D. Front Physiol. 2020 Jan 22;10:1599. PMID: 32038284 PMCID: PMC6987461 DOI: 10.3389/fphys.2019.01599

HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature.

DiFrancesco JC, Castellotti B, Milanesi R, Ragona F, Freri E, Canafoglia L, Franceschetti S, Ferrarese C, Magri S, Taroni F, Costa C, Labate A, Gambardella A, Solazzi R, Binda A, Rivolta I, Di Gennaro G, Casciato S, D'Incerti L, Barbuti A, DiFrancesco D, Granata T, Gellera C.  (2019). Epilepsy Research 153:49-58. DOI: 10.1016/j.eplepsyres.2019.04.004

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If “funny” current.

Baruscotti M., Bianco E., Bucchi, A., DiFrancesco, D. (2016) Journal of Interventional Cardiac Electrophysiology 46(1):19-28. PMID: 26781742 DOI: 10.1007/s10840-015-0097-y

Dysfunctional HCN ion channels in neurological diseases.

DiFrancesco J.C., DiFrancesco D. (2015) Frontiers in Cellular Neuroscience 9:71. PMID: 25805968 PMCID: PMC4354400 DOI: 10.3389/fncel.2015.00071

HCN4, Sinus Bradycardia and Atrial Fibrillation.

DiFrancesco D. (2015) Arrhythmia & Electrophysiology Review 4(1):9-13. PMID: 26835093 PMCID: PMC4711571 DOI: 10.15420/aer.2015.4.1.9

Funny channel gene mutations associated with arrhythmias.

DiFrancesco, D. (2013) J. Physiol. 591.17: 4117–4124. PMID: 23507880 PMCID: PMC3779106 DOI: 10.1113/jphysiol.2013.253765

Funny current and cardiac rhythm: insights from HCN knockout mouse models.

Bucchi A., Barbuti A., DiFrancesco D. & Baruscotti M. (2012) Frontiers in Physiology 3(240):1-10. PMID: 22783204 PMCID: PMC3387723 DOI: 10.3389/fphys.2012.00240

Rebuttal to "The funny current in the context of the coupled clock pacemaker cell system" by Victor A. Maltsev and Edward G. Lakatta

DiFrancesco, D., Noble, D. (2012). Heart Rhythm 9(3):457:458. PMID: 21925135 DOI: 10.1016/j.hrthm.2011.09.023

The funny current has a major pacemaking role in the sinus node.

DiFrancesco, D., Noble, D. (2012) Heart Rhythm 9(2):299-301. PMID: 21925134 DOI: 10.1016/j.hrthm.2011.09.021

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised Reporting for Model Reproducibility, Interoperability, and Data Sharing.

Quinn TA, Bollensdorff C, Bub G, Burton RAB, DiFrancesco,D, Earm YE, Fink M, Hunter PJ, Garny A, Granite S, Hannes T, Lord P, McCulloch AD, Mirams GR, Noble D, Rosenbaum DS, Trayanova NA, Ravens U, Wang K, Winslow RL, Kohl P (2011) Progress in Biophysics and Molecular Biology 107: 4-10. PMID: 21745496 PMCID: PMC3190048 DOI: 10.1016/j.pbiomolbio.2011.07.001

Baruscotti M, Bottelli G, Milanesi R, DiFrancesco JC, DiFrancesco D. (2010) Pflügers Arch. 460(2):405-15. PMID: 20213494 DOI: 10.1007/s00424-010-0810-8

The role of the funny current in pacemaker activity

DiFrancesco, D. (2010) . Circulation Research 210: 434-446. PMID: 20167941 DOI: 10.1161/CIRCRESAHA.109.208041

Viewpoint: Funny channel-based pacemaking.

DiFrancesco,D. (2010) Heart Rhythm 7(2):276-279. PMID: 20022815 DOI: 10.1016/j.hrthm.2009.10.030

Control Of Cardiac Rate by “Funny” Channels In Health And Disease.

Barbuti, A. & DiFrancesco, D. (2008) Ann. N.Y. Acad. Sci. 1123, 213-223. PMID: 18375593 DOI: 10.1196/annals.1420.024

The pacemaker funny channel: a tool to control heart rate

DiFrancesco, D. (2007) Medicographia 29(4) 319-325

The Funny current: cellular basis for control of heart rate.

DiFrancesco, D. & Borer, J.S. (2007) Drugs 67 Supp. 2, 1-11. PMID: 17999560 DOI: 10.2165/00003495-200767002-00003

The Pacemaker Current: From Basics to the Clinics.

Barbuti, A., Baruscotti, M & DiFrancesco, D. (2007) J. Cardiovasc. Electrophysiol. 18, 1-6. PMID: 17284289DOI: 10.1111/j.1540-8167.2006.00736.x

Heart rate reduction via selective ‘funny’ channel blockers.

Bucchi, A., Barbuti, A., Baruscotti, M & DiFrancesco, D. (2007) Curr. Opin. Pharmacol. 7, 208-213. PMID: 17267284 DOI: 10.1016/j.coph.2006.09.005

Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

DiFrancesco, D. (2006) Pharmacological Research 53, 399-406. PMID: 16638640 DOI: 10.1016/j.phrs.2006.03.006

Cardiac pacemaker (If) current: physiological and pharmacological properties.

DiFrancesco, D. (2006) Hospital Chronicles (Nosokomeiaka Chronika) 1(1), 151-155.

Serious workings of the funny current.

DiFrancesco, D. (2006) Prog. Biophys. Mol. Biol. 90, 13–25. PMID: 15975637 DOI: 10.1016/j.pbiomolbio.2005.05.001

If current in cardiology.

DiFrancesco, D. (2005) Advances in Heart Rate Reduction N. 4, 4-7.

Cardiac pacemaker If current and its inhibition by heart rate–reducing agents

DiFrancesco, D. (2005) Curr Med Res Opin 21(7): 1115-22

Physiology and pharmacology of the cardiac pacemaker (“funny”) current.

Baruscotti,M., Bucchi, A. & DiFrancesco,D. (2005) Pharmacology & Therapeutics 57(1), 59-79

Pacemaker channels.

Baruscotti,M. & DiFrancesco,D. (2004) Ann. N.Y. Acad. Sci. 1015:111-21

Heart Rate Lowering by Specific and Selective If Inhibition with Ivabradine: A New Therapeutic Perspective in Cardiovascular Disease.

DiFrancesco, D. & Camm, J.A. (2004) Drugs 64 (16), 1-10. DOI: 10.2165/00003495-200464160-00003

If inhibition: a novel mechanism of action

DiFrancesco, D. (2003) Eur. Heart J. Supplements 5, Issue suppl. G, 1 Sept 2003, G19-G25

Sino-atrial If current: a target for specific heart rate reduction.

DiFrancesco, D. (2002) Medicographia 24-3, 218-224

From funny current to HCN channels: 20 years of excitation.

Accili,E.A., Proenza,C., Baruscotti,M. & DiFrancesco, D. (2002) News Physiol. Sci. 17, 32-37. DOI: 10.1152/physiologyonline.2002.17.1.32

The funny current.

DiFrancesco,D. (1999) The Physiological Society Magazine 37, 4-5

Cardiac pacemaker: 15 years of "new" interpretation.

DiFrancesco,D. (1995b)Acta Cardiologica Vol. L, 6, 413-427. PMID: 8932564

The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f-current.

DiFrancesco,D. (1995a) Cardiovascular Res. 29, 449-456. PMID: 7540954

Ionic mechanisms in the autonomic modulation of sinoatrial pacemaking. In "Basic problems of cardiac automaticity"

Zaza, A. & DiFrancesco,D. (1993) Prog. Pharmacol. Res. vol. 2. Ed. B. Guth, ULM, Biberach, pp. 45-56

Pacemaker mechanisms in cardiac tissue.

DiFrancesco,D. (1993) Ann. Rev. Physiol. 55, 455-472. DOI: 10.1146/

The cardiac pacemaker current, if.

DiFrancesco,D. & Zaza, A. (1992) J. Cardiovasc. Electrophysiol. 3, 334-344

Role of if current in pacemaker cells.

DiFrancesco,D. (1991c) Role of if current in pacemaker cells. Prog. Pharmacol. Res. 1, 39

Generation and control of cardiac pacing: the pacemaker current.

DiFrancesco,D. (1991) Trends Cardiovasc. Med. 1, 250-255. DOI: 10.1016/1050-1738(91)90030-I

The pacemaker current in the sinus node.

DiFrancesco,D. (1987) Europ. Heart J. 8, suppl, 19-23. DOI: 10.1093/eurheartj/8.suppl_l.19

The cardiac hyperpolarizing-activated current, if. Origins and developments.

DiFrancesco,D. (1985) Prog. Biophys. molec. Biol. 46, 163-183. DOI: 10.1016/0079-6107(85)90008-2